- Course name: Physical methods in chemical analysis
- Code course: 2104199
- Semester credit: 2 (2, 0, 4)
- Degree: Fourth year student
- Course hours
– Class 30 hours
– Laboratory 0 hour
– Home study 60 hours
– To provide the student with basic principles of physical chemical analysis methods.
– To deepen the student understands of the principles of spectroscopy, chromatography and electrochemistry.
– To increase the student’s ability to communicate effectively and professionally both in writing and in speech.
– To develop the student’s ability to read, interpret and understand modern professional chemical literature.
– To foster, encourage and develop critical thinking and higher-order creative thinking in the student.
- Course Description
This course will address the following topics: A review the course covers instrumental methods of analysis which covers electrochemical method of potentiometric and voltammetry analyses, spectrophotometric methods such as: UV-Vis, IR, fluorescence and NMR; and chromatographic methods such as paper chromatography, HPLC, GC and LCMS.
Class attandance, assay, examine acording to the regulation No. 43/2007-QĐ-BGD&ĐT date 15/08/2007 of MOET, regulation No 235/QĐ-ĐHCN-ĐT date 30/08/2007 of IUH.
- Course material:
– Textbook:
Hồ Viết Quý, Physical chemical analysis, NXB Giáo dục, 2001.
– Reference:
- Joseph Wang, Analytical electrochemistry, Wiley-VCH, 2000.
- Walter Jennings, Eric Mittlefehldt, Philip Stremple, Analytical gas chromatography, J&W Scientific Folsom Califonia, 1997.
- F.W. Fifield, Principles and Practice of Analytical Chemistry, Blackwell Science, 2000.
- 4. Douglas A. Skoog, Jame J. Leary, Principles of instrumental analylsis-Samders collge puslishing, 1992.
- 5. Ahuja S., Jespersen, Modern Instrumental analysis, Elsevier, 2006.
- Grades:
– Class Participation: yes
– Assay: no
– Short quizzes: no
– Mid term: yes
– Final term: yes
– Other: seminar
- Grade Rule: Follow the credit regulation
- Course Outline:
| No | Main Contents | Hours | Credit Hours | Note | ||
| Class | Lab | Home study | ||||
| 1 | Spectroscopy methods of analysis | 10 | 10 | 20 | ||
| 2 | Mass spectrometry and Nuclear magnetic resonance spectroscopy of analysis | 4 | 4 | 8 | ||
| 3 | Chromatography methods of analysis | 8 | 8 | 16 | ||
| 4 | Electrochemical methods of analysis | 8 | 8 | 16 | ||
| Total | 30 | 30 | 60 | |||
Chapter 1: Spectroscopy methods of analysis
1.1. Fundamental concepts
1.1.1. The nature and laws of light
1.1.2. Classification of spectral methods
1.2. Ultraviolet–visible spectroscopy
1.2.1. Electron excitation and energy transfer rates
1.2.2. Instrumentation
1.2.4. Applications of UV-VIS absorption spectroscopy
1.3. Atomic Absorption Spectrometry and atomic emission spectroscopy methods
1.3.1. Fundamental concepts
1.3.2. Instrumentation
1.3.3. Applications of AAS and AES
1.4.1 Fundamental concepts
1.4.2. Instrumentation
1.4.3. Applications of IR
1.5. Fluorescence and phosphorescence spectroscopy methods
1.5.1. Jablonski schema
1.5.2. Instrumentation
1.5.3. Applications of fluorescence and phosphorescence spectroscopy
Chapter 2: Mass spectrometry and Nuclear magnetic resonance spectroscopy of analysis
2.1. Mass spectrometry
2.1.1. Fundamental concepts
2.1.2. Instrumentation
2.1.3. Mass Spectrometry Ionization Techniques
2.1.4. Application of mass spectrometry in the structural analysis of component organics
2.2. Nuclear magnetic resonance
2.2.1. Fundamental concepts
2.2.2. Instrumentation
2.2.3. Application of nuclear magnetic resonance
Chapter 3: Chromatography methods of analysis
3.1. Fundamental concepts
3.1.1. Basic concepts and terms
3.1.2. Van Deemter equation
3.1.3. Classification of chromatographic methods
3.2. High performance liquid chromatography (HPLC)
3.2.1. Stationary phases
3.2.2. Mobile phases
3.2.3. Instrumentation
3.2.4. Qualitative and quantitative analysis
3.3. Gas chromatography (GC)
3.3.1. Stationary phases
3.3.2. Carrier gas
3.3.3. Instrumentation
3.3.4. Qualitative and quantitative analysis
3.4. Ion exchange chromatography (IEC)
3.4.1. Principles
3.4.2. Stationary phases
3.4.3. Mobile phase
3.4.4. Instrumentation
Chapter 4: Electrochemical methods of analysis
4.1. Fundamental concepts
4.1.1. Electrolysis
4.1.2. Electrode processes
4.1.3. Classification of electrochemical
4.2. Potentiometric
4.2.1. Principles of potentiometric measurements
4.2.2. Indicator and reference electrodes
4.2.3. Potentiometric titration
4.3. Polarography and voltammetry methods
4.3.1. Direct current methods
4.3.2. Pulse methods
4.3.3. Alternating current methods
4.3.4. Stripping methods
4.3.5. Instrumentation
4.3.6. Application of polarography and volammetry
4.4. Karl Fischer titration (KF)
4.4.1. Motivation
4.4.2. Volumetric KF titration
4.4.3. Coulometric KF titration
4.4.4. Instrumentation
4.4.5. Application of KF
